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Open Access Article

Orthopedics and Sports Medicine. 2025; 1: (1) ; 1-8 ; DOI: 10.12208/j.osm.20250001.

Research progress on risk factors and treatment strategies for the coexistence of osteoporosis in COPD patients
慢性阻塞性肺疾病患者并发骨质疏松的危险因素及治疗策略研究进展

作者: Chunmei He, Ruicheng Hu *

湖南师范大学第一附属医院(湖南省人民医院)呼吸内科 湖南长沙

*通讯作者: Ruicheng Hu,单位:湖南师范大学第一附属医院(湖南省人民医院)呼吸内科 湖南长沙;

发布时间: 2025-05-09 总浏览量: 358

摘要

骨质疏松症(OP)是一种可由慢性阻塞性肺疾病(COPD)诱发的全身性疾病,会加重COPD患者的病情,影响预后和生活质量,并增加潜在死亡风险。OP早期症状不明显,容易导致治疗疏忽,早期诊断COPD患者OP具有重要的临床意义。本文总结了COPD合并OP的危险因素及治疗进展。COPD合并OP的危险因素主要包括吸烟、炎症反应、年龄、药物作用、维生素D缺乏、性别、缺乏运动、低氧血症、体质指数、激素水平、氧化应激等。目前,COPD合并OP的基本治疗原则是两者并举,将OP治疗纳入COPD治疗计划。常用的抗OP药物分为促进骨形成、矿化和抑制骨吸收三类。中医药在治疗COPD合并OP方面也显示出了相当的疗效。

关键词: 慢性阻塞性肺疾病;骨质疏松症;危险因素;治疗;研究进展

Abstract

Osteoporosis (OP) is a systemic condition that can be induced by chronic obstructive pulmonary disease (COPD), further exacerbating the condition in COPD patients, impacting prognosis and quality of life, and increasing the risk of potential mortality. Early symptoms of OP are not evident, leading to potential treatment oversight. Early diagnosis of OP in COPD patients holds crucial clinical significance. This article summarizes the risk factors and treatment progress of COPD patients with concomitant OP. The risk factors for COPD patients with concomitant OP mainly include smoking, inflammatory response, age, medication effects, vitamin D deficiency, gender, lack of exercise, hypoxemia, body mass index, hormone levels, oxidative stress, and others. Currently, the basic treatment principle for COPD combined with OP is to manage both conditions simultaneously, integrating OP treatment into the COPD treatment plan. Commonly used anti-OP medications are categorized into those promoting bone formation, mineralization, and inhibiting bone resorption. Traditional Chinese medicine has also shown considerable efficacy in the treatment of COPD combined with OP.

Key words: Chronic obstructive pulmonary disease; Osteoporosis; Risk factors; Treatment; Research progress

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引用本文

ChunmeiHe, RuichengHu, 慢性阻塞性肺疾病患者并发骨质疏松的危险因素及治疗策略研究进展[J]. 骨科与运动医学, 2025; 1: (1) : 1-8.